Structure and inhibition of mouse leukotriene C4 synthase.

Structure and inhibition of mouse leukotriene C4 synthase.

Leukotriene (LT) C4 synthase (LTC4S) is an integral membrane protein that catalyzes the conjugation reaction between the fatty acid LTA4 and GSH to form the pro-inflammatory LTC4, an important mediator of asthma. Mouse models of inflammatory disorders such as asthma are key to improve our understand...

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Bibliographic Details
Main Authors: Damian Niegowski, Thea Kleinschmidt, Shabbir Ahmad, Abdul Aziz Qureshi, Michaela Mårback, Agnes Rinaldo-Matthis, Jesper Z Haeggström
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4014545?pdf=render

Internet

http://europepmc.org/articles/PMC4014545?pdf=render

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