Ligand-directed functional selectivity at the mu opioid receptor revealed by label-free integrative pharmacology on-target.

Development of new opioid drugs that provide analgesia without producing dependence is important for pain treatment. Opioid agonist drugs exert their analgesia effects primarily by acting at the mu opioid receptor (MOR) sites. High-resolution differentiation of opioid ligands is crucial for the deve...

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Bibliographic Details
Main Authors: Megan Morse, Elizabeth Tran, Haiyan Sun, Robert Levenson, Ye Fang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22003401/?tool=EBI