Selenomethionine incorporation into amyloid sequences regulates fibrillogenesis and toxicity.

Selenomethionine incorporation into amyloid sequences regulates fibrillogenesis and toxicity.

BACKGROUND: The capacity of a polypeptide chain to engage in an amyloid formation process and cause a conformational disease is contained in its sequence. Some of the sequences undergoing fibrillation contain critical methionine (Met) residues which in vivo can be synthetically substituted by seleno...

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Bibliographic Details
Main Authors: Javier Martínez, Silvia Lisa, Rosa Sánchez, Wioleta Kowalczyk, Esther Zurita, Meritxell Teixidó, Ernest Giralt, David Andreu, Jesús Avila, María Gasset
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3222675?pdf=render

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http://europepmc.org/articles/PMC3222675?pdf=render

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