Quality by Design Methodology Applied to Process Optimization and Scale up of Curcumin Nanoemulsions Produced by Catastrophic Phase Inversion

Quality by Design Methodology Applied to Process Optimization and Scale up of Curcumin Nanoemulsions Produced by Catastrophic Phase Inversion

In the presented study, we report development of a stable, scalable, and high-quality curcumin-loaded oil/water (o/w) nanoemulsion manufactured by concentration-mediated catastrophic phase inversion as a low energy nanoemulsification strategy. A design of experiments (DoE) was constructed to determi...

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Bibliographic Details
Main Authors: Sandeep Kumar Reddy Adena, Michele Herneisey, Eric Pierce, Paul R. Hartmeier, Suneera Adlakha, Marco A. I. Hosfeld, James K. Drennen, Jelena M. Janjic
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Pharmaceutics
Subjects:
nanoemulsion
catastrophic phase inversion
quality by design
multiple linear regression
Online Access:https://www.mdpi.com/1999-4923/13/6/880

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https://www.mdpi.com/1999-4923/13/6/880

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