ZNF198-FGFR1 Transforms Ba/F3 Cells to Growth Factor Independence and Results in High Level Tyrosine Phosphorylation of STATS 1 and 5

ZNF198-FGFR1 Transforms Ba/F3 Cells to Growth Factor Independence and Results in High Level Tyrosine Phosphorylation of STATS 1 and 5

The ZNF198-FGFR1 fusion gene arises as a result of the t(8;13)(p11;g12) in the 8p11 myeloproliferative syndrome. To determine the transforming properties of this chimeric protein we transfected ZNF198-FGFR1 into the interleukin (IL)-3 dependent cell line Ba/F3. Growth factor independent subclones w...

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Bibliographic Details
Main Authors: Damian Smedley, Asuman Demiroglu, Munah Abdul-Rauf, Carol Heatht, Colin Cooper, Janet Shipley, Nicholas C.P. Cross
Format: Article
Language:English
Published: Elsevier 1999-10-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
ZNF198
FGFR1
t(8;13)
tyrosine kinase
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558699800268

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http://www.sciencedirect.com/science/article/pii/S1476558699800268

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