Role of the NMDA-receptor in Prepulse Inhibition in the Rat

Kynurenic acid (KYNA) is an endogenous metabolite of tryptophan. Studies have revealed increased brain KYNA levels in patients with schizophrenia. Prepulse inhibition (PPI) is a behavioral model for sensorimotor gating and found to be reduced in schizophrenia. Previous studies have shown that pharma...

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Bibliographic Details
Main Authors: Klas Linderholm, Susan Powell, Elin Olsson, Maria Holtze, Ralph Snodgrass, Sophie Erhardt
Format: Article
Language:English
Published: SAGE Publishing 2010-02-01
Series:International Journal of Tryptophan Research
Online Access:http://la-press.com/role-of-the-nmda-receptor-in-prepulse-inhibition-in-the-rat-a1855