Identification of influential proteins in the classical retinoic acid signaling pathway

Identification of influential proteins in the classical retinoic acid signaling pathway

Abstract Background In the classical pathway of retinoic acid (RA) mediated gene transcription, RA binds to a nuclear hormone receptor dimer composed of retinoic acid receptor (RAR) and retinoid X receptor (RXR), to induce the expression of its downstream target genes. In addition to nuclear recepto...

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Bibliographic Details
Main Authors: Hamed Ghaffari, Linda R. Petzold
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Theoretical Biology and Medical Modelling
Subjects:
Retinoic acid
Cellular retinoic acid binding protein
Retinoic acid signaling pathway
Retinoic acid receptor
Mathematical model
Global sensitivity analysis
Online Access:http://link.springer.com/article/10.1186/s12976-018-0088-7

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http://link.springer.com/article/10.1186/s12976-018-0088-7

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