Conservation of S20 as an Ineffective and Disposable IFNγ-Inducing Determinant of Plasmodium Sporozoites Indicates Diversion of Cellular Immunity

Conservation of S20 as an Ineffective and Disposable IFNγ-Inducing Determinant of Plasmodium Sporozoites Indicates Diversion of Cellular Immunity

Despite many decades of research to develop a malaria vaccine, only one vaccine candidate has been explored in pivotal phase III clinical trials. This candidate subunit vaccine consists of a portion of a single Plasmodium antigen, circumsporozoite protein (CSP). This antigen was initially identified...

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Bibliographic Details
Main Authors: Calvin Hon, Johannes Friesen, Alyssa Ingmundson, Diana Scheppan, Julius C. R. Hafalla, Katja Müller, Kai Matuschewski
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Microbiology
Subjects:
malaria
Plasmodium
sporozoite
whole organism vaccine
antigen
CD8+ T cells
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.703804/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2021.703804/full

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