Identification of Four Mouse Diabetes Candidate Genes Altering β-Cell Proliferation.

Identification of Four Mouse Diabetes Candidate Genes Altering β-Cell Proliferation.

Beta-cell apoptosis and failure to induce beta-cell regeneration are hallmarks of type 2-like diabetes in mouse models. Here we show that islets from obese, diabetes-susceptible New Zealand Obese (NZO) mice, in contrast to diabetes-resistant C57BL/6J (B6)-ob/ob mice, do not proliferate in response t...

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Main Authors: Oliver Kluth, Daniela Matzke, Anne Kamitz, Markus Jähnert, Heike Vogel, Stephan Scherneck, Matthias Schulze, Harald Staiger, Fausto Machicao, Hans-Ulrich Häring, Hans-Georg Joost, Annette Schürmann
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-09-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4562707?pdf=render

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http://europepmc.org/articles/PMC4562707?pdf=render

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