ERRα-Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer

ERRα-Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer

Imaging studies in animals and in humans have indicated that the oxygenation and nutritional status of solid tumors is dynamic. Furthermore, the extremely low level of glucose within tumors, while reflecting its rapid uptake and metabolism, also suggests that cancer cells must rely on other energy s...

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Bibliographic Details
Main Authors: Sunghee Park, Ching-Yi Chang, Rachid Safi, Xiaojing Liu, Robert Baldi, Jeff S. Jasper, Grace R. Anderson, Tingyu Liu, Jeffrey C. Rathmell, Mark W. Dewhirst, Kris C. Wood, Jason W. Locasale, Donald P. McDonnell
Format: Article
Language:English
Published: Elsevier 2016-04-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716302820

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http://www.sciencedirect.com/science/article/pii/S2211124716302820

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