Impact of downstream effects of glucocorticoid receptor dysfunction on organ function in critical illness-associated systemic inflammation
Abstract Glucocorticoids (GCs) are stress hormones that regulate developmental and physiological processes and are among the most potent anti-inflammatory drugs to suppress chronic and acute inflammation. GCs act through the glucocorticoid receptor (GR), a ubiquitously expressed ligand-activated tra...
Main Authors: | , , , , , , |
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Format: | Article |
Language: | English |
Published: |
SpringerOpen
2020-12-01
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Series: | Intensive Care Medicine Experimental |
Subjects: | |
Online Access: | https://doi.org/10.1186/s40635-020-00325-z |