Impact of downstream effects of glucocorticoid receptor dysfunction on organ function in critical illness-associated systemic inflammation

Impact of downstream effects of glucocorticoid receptor dysfunction on organ function in critical illness-associated systemic inflammation

Abstract Glucocorticoids (GCs) are stress hormones that regulate developmental and physiological processes and are among the most potent anti-inflammatory drugs to suppress chronic and acute inflammation. GCs act through the glucocorticoid receptor (GR), a ubiquitously expressed ligand-activated tra...

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Bibliographic Details
Main Authors: Martin Wepler, Jonathan M. Preuss, Tamara Merz, Oscar McCook, Peter Radermacher, Jan P. Tuckermann, Sabine Vettorazzi
Format: Article
Language:English
Published: SpringerOpen 2020-12-01
Series:Intensive Care Medicine Experimental
Subjects:
Glucocorticoid receptor
Dysfunction
Monomer
Dimer
Systemic inflammation
Mouse models
Online Access:https://doi.org/10.1186/s40635-020-00325-z

Internet

https://doi.org/10.1186/s40635-020-00325-z

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