Marked augmentation of PLGA nanoparticle-induced metabolically beneficial impact of γ-oryzanol on fuel dyshomeostasis in genetically obese-diabetic ob/ob mice

Marked augmentation of PLGA nanoparticle-induced metabolically beneficial impact of γ-oryzanol on fuel dyshomeostasis in genetically obese-diabetic ob/ob mice

Our previous works demonstrated that brown rice-specific bioactive substance, γ-oryzanol acts as a chaperone, attenuates exaggerated endoplasmic reticulum (ER) stress in brain hypothalamus and pancreatic islets, thereby ameliorating metabolic derangement in high fat diet (HFD)-induced obese diabetic...

Full description

Bibliographic Details
Main Authors: Chisayo Kozuka, Chigusa Shimizu-Okabe, Chitoshi Takayama, Kaku Nakano, Hidetaka Morinaga, Ayano Kinjo, Kotaro Fukuda, Asuka Kamei, Akihito Yasuoka, Takashi Kondo, Keiko Abe, Kensuke Egashira, Hiroaki Masuzaki
Format: Article
Language:English
Published: Taylor & Francis Group 2017-01-01
Series:Drug Delivery
Subjects:
type 2 diabetes mellitus
brown rice
γ-oryzanol
nanotechnology
poly (dl-lactide-co-glycolide)
obesity
therapeutic modality
Online Access:http://dx.doi.org/10.1080/10717544.2017.1279237

Internet

http://dx.doi.org/10.1080/10717544.2017.1279237

Similar Items