Use of whole-genome sequencing to distinguish relapse from reinfection in a completed tuberculosis clinical trial

Use of whole-genome sequencing to distinguish relapse from reinfection in a completed tuberculosis clinical trial

Abstract Background RIFAQUIN was a tuberculosis chemotherapy trial in southern Africa including regimens with high-dose rifapentine with moxifloxacin. Here, the application of whole-genome sequencing (WGS) is evaluated within RIFAQUIN for identifying new infections in treated patients as either rela...

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Bibliographic Details
Main Authors: Adam A. Witney, Anna L. E. Bateson, Amina Jindani, Patrick P. J. Phillips, David Coleman, Neil G. Stoker, Philip D. Butcher, Timothy D. McHugh, RIFAQUIN Study Team
Format: Article
Language:English
Published: BMC 2017-03-01
Series:BMC Medicine
Subjects:
Whole genome sequencing
Tuberculosis
Clinical trial
Online Access:http://link.springer.com/article/10.1186/s12916-017-0834-4

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http://link.springer.com/article/10.1186/s12916-017-0834-4

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