TrkB Agonist LM22A-4 Increases Oligodendroglial Populations During Myelin Repair in the Corpus Callosum

TrkB Agonist LM22A-4 Increases Oligodendroglial Populations During Myelin Repair in the Corpus Callosum

The neurotrophin, brain-derived neurotrophic factor (BDNF) promotes central nervous system (CNS) myelination during development and after injury. This is achieved via activation of oligodendrocyte-expressed tropomyosin-related kinase (Trk) B receptors. However, while administration of BDNF has shown...

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Bibliographic Details
Main Authors: Huynh T. H. Nguyen, Rhiannon J. Wood, Alexa R. Prawdiuk, Sebastian G. B. Furness, Junhua Xiao, Simon S. Murray, Jessica L. Fletcher
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Molecular Neuroscience
Subjects:
myelin
neurotrophin
oligodendrocytes
remyelination
TrkB
BDNF
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2019.00205/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2019.00205/full

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