Novel Benzene-Based Carbamates for AChE/BChE Inhibition: Synthesis and Ligand/Structure-Oriented SAR Study

Novel Benzene-Based Carbamates for AChE/BChE Inhibition: Synthesis and Ligand/Structure-Oriented SAR Study

A series of new benzene-based derivatives was designed, synthesized and comprehensively characterized. All of the tested compounds were evaluated for their in vitro ability to potentially inhibit the acetyl- and butyrylcholinesterase enzymes. The selectivity index of individual molecules to cholines...

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Bibliographic Details
Main Authors: Andrzej Bak, Violetta Kozik, Dariusz Kozakiewicz, Kamila Gajcy, Daniel Jan Strub, Aleksandra Swietlicka, Sarka Stepankova, Ales Imramovsky, Jaroslaw Polanski, Adam Smolinski, Josef Jampilek
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:International Journal of Molecular Sciences
Subjects:
benzene-based carbamates
in vitro cholinesterase inhibition
CoMSA
IVE-PLS
molecular docking study
Online Access:https://www.mdpi.com/1422-0067/20/7/1524

Internet

https://www.mdpi.com/1422-0067/20/7/1524

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