An optimized library for reference-based deconvolution of whole-blood biospecimens assayed using the Illumina HumanMethylationEPIC BeadArray

An optimized library for reference-based deconvolution of whole-blood biospecimens assayed using the Illumina HumanMethylationEPIC BeadArray

Abstract Genome-wide methylation arrays are powerful tools for assessing cell composition of complex mixtures. We compare three approaches to select reference libraries for deconvoluting neutrophil, monocyte, B-lymphocyte, natural killer, and CD4+ and CD8+ T-cell fractions based on blood-derived DNA...

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Bibliographic Details
Main Authors: Lucas A. Salas, Devin C. Koestler, Rondi A. Butler, Helen M. Hansen, John K. Wiencke, Karl T. Kelsey, Brock C. Christensen
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Genome Biology
Subjects:
DNA methylation
Epigenetics
Neutrophils
Monocytes
Natural killer cells
B-cells
Online Access:http://link.springer.com/article/10.1186/s13059-018-1448-7

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