Decoy Receptor 3 Inhibits Monosodium Urate-Induced NLRP3 Inflammasome Activation via Reduction of Reactive Oxygen Species Production and Lysosomal Rupture

Decoy Receptor 3 Inhibits Monosodium Urate-Induced NLRP3 Inflammasome Activation via Reduction of Reactive Oxygen Species Production and Lysosomal Rupture

Gout is a common inflammatory arthritis caused by the deposition of monosodium urate (MSU) crystals in the joints. This activates the macrophages into a proinflammatory state by inducing NLRP3-dependent interleukin-1β (IL-1β) secretion, resulting in neutrophil recruitment. Soluble decoy receptor 3 (...

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Bibliographic Details
Main Authors: Yi-Gen Pan, Ming-Ting Huang, Ponarulselvam Sekar, Duen-Yi Huang, Wan-Wan Lin, Shie-Liang Hsieh
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
decoy receptor 3
NLRP3 inflammasome
lysosome
gout
reactive oxygen species
monosodium urate
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.638676/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.638676/full

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