Helminth infections coincident with active pulmonary tuberculosis inhibit mono- and multifunctional CD4+ and CD8+ T cell responses in a process dependent on IL-10.

Helminth infections coincident with active pulmonary tuberculosis inhibit mono- and multifunctional CD4+ and CD8+ T cell responses in a process dependent on IL-10.

Tissue invasive helminth infections and tuberculosis (TB) are co-endemic in many parts of the world and can trigger immune responses that might antagonize each other. We have previously shown that helminth infections modulate the Th1 and Th17 responses to mycobacterial-antigens in latent TB. To dete...

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Bibliographic Details
Main Authors: Parakkal Jovvian George, Rajamanickam Anuradha, Nathella Pavan Kumar, Rathinam Sridhar, Vaithilingam V Banurekha, Thomas B Nutman, Subash Babu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-09-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4161445?pdf=render

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http://europepmc.org/articles/PMC4161445?pdf=render

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