Epsin15 Homology Domains: Role in the Pathogenesis of Pulmonary Arterial Hypertension

Epsin15 Homology Domains: Role in the Pathogenesis of Pulmonary Arterial Hypertension

Intersectin-1s (ITSN) deficiency and expression of a biologically active ITSN fragment, result of granzyme B cleavage under inflammatory conditions associated with pulmonary arterial hypertension (PAH), are characteristics of lung tissue of human and animal models of PAH. Recently, we have shown tha...

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Bibliographic Details
Main Authors: Dan Predescu, Shanshan Qin, Monal Patel, Cristina Bardita, Rabia Bhalli, Sanda Predescu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Physiology
Subjects:
intersectin
pulmonary arterial hypertension
endocytic deficiency
alternative transport pathways
non-conventional endocytic/transcytotic structures
EH-binding protein 1
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.01393/full

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https://www.frontiersin.org/article/10.3389/fphys.2018.01393/full

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