MicroRNAs targeting Nicastrin regulate Aβ production and are affected by target site polymorphisms

MicroRNAs targeting Nicastrin regulate Aβ production and are affected by target site polymorphisms

Despite the growing number of genome-wide association studies, the involvement of polymorphisms in microRNA target sites (polymiRTS) in Alzheimer’s disease (AD) remains poorly investigated. Recently, we have shown that AD-associated single nucleotide polymorphisms (SNPs) present in the 3’untranslate...

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Bibliographic Details
Main Authors: Charlotte eDelay, Véronique eDorval, Alice eFok, Benjamin eGrenier-Boley, Jean-Charles eLambert, G-Y eHsiung, Sebastien S Hebert
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-07-01
Series:Frontiers in Molecular Neuroscience
Subjects:
microRNA
Alzheimer’s disease
Single nucleotide polymorphism
nicastrin
miR-186
miR-455
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2014.00067/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnmol.2014.00067/full

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