Enhanced gastrointestinal expression of cytosolic malic enzyme (ME1) induces intestinal and liver lipogenic gene expression and intestinal cell proliferation in mice.

Enhanced gastrointestinal expression of cytosolic malic enzyme (ME1) induces intestinal and liver lipogenic gene expression and intestinal cell proliferation in mice.

The small intestine participates in lipid digestion, metabolism and transport. Cytosolic malic enzyme 1 (ME1) is an enzyme that generates NADPH used in fatty acid and cholesterol biosynthesis. Previous work has correlated liver and adipose ME1 expression with susceptibility to obesity and diabetes;...

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Bibliographic Details
Main Authors: Ahmed Al-Dwairi, Adam R Brown, John Mark P Pabona, Trang H Van, Hamdan Hamdan, Charles P Mercado, Charles M Quick, Patricia A Wight, Rosalia C M Simmen, Frank A Simmen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4234650?pdf=render

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http://europepmc.org/articles/PMC4234650?pdf=render

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