Transmembrane Polar Relay Drives the Allosteric Regulation for ABCG5/G8 Sterol Transporter

Transmembrane Polar Relay Drives the Allosteric Regulation for ABCG5/G8 Sterol Transporter

The heterodimeric ATP-binding cassette (ABC) sterol transporter, ABCG5/G8, is responsible for the biliary and transintestinal secretion of cholesterol and dietary plant sterols. Missense mutations of ABCG5/G8 can cause sitosterolemia, a loss-of-function disorder characterized by plant sterol accumul...

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Bibliographic Details
Main Authors: Bala M. Xavier, Aiman A. Zein, Angelica Venes, Junmei Wang, Jyh-Yeuan Lee
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
ABCG5
ABCG8
ATP-binding cassette transporter
cholesterol
polar relay
sitosterolemia
Online Access:https://www.mdpi.com/1422-0067/21/22/8747

Internet

https://www.mdpi.com/1422-0067/21/22/8747

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