Synthetic Fosmidomycin Analogues with Altered Chelating Moieties Do Not Inhibit 1-Deoxy-D-xylulose 5-phosphate Reductoisomerase or Plasmodium falciparum Growth In Vitro

Synthetic Fosmidomycin Analogues with Altered Chelating Moieties Do Not Inhibit 1-Deoxy-D-xylulose 5-phosphate Reductoisomerase or Plasmodium falciparum Growth In Vitro

Fourteen new fosmidomycin analogues with altered metal chelating groups were prepared and evaluated for inhibition of E. coli Dxr, M. tuberculosis Dxr and the growth of P. falciparum K1 in human erythrocytes. None of the synthesized compounds showed activity against either enzyme or the Plasmodia. T...

Full description

Bibliographic Details
Main Authors: René Chofor, Martijn D.P. Risseeuw, Jenny Pouyez, Chinchu Johny, Johan Wouters, Cynthia S. Dowd, Robin D. Couch, Serge Van Calenbergh
Format: Article
Language:English
Published: MDPI AG 2014-02-01
Series:Molecules
Subjects:
fosmidomycin
DOXP reductoisomerase
non-mevalonate pathway
isoprenoid biosynthesis
coordination chemistry
Online Access:http://www.mdpi.com/1420-3049/19/2/2571

Internet

http://www.mdpi.com/1420-3049/19/2/2571

Similar Items