Silicosis and Silica-Induced Autoimmunity in the Diversity Outbred Mouse

Silicosis and Silica-Induced Autoimmunity in the Diversity Outbred Mouse

Epidemiological studies have confidently linked occupational crystalline silica exposure to autoimmunity, but pathogenic mechanisms and role of genetic predisposition remain poorly defined. Although studies of single inbred strains have yielded insights, understanding the relationships between lung...

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Bibliographic Details
Main Authors: Jessica M. Mayeux, Gabriela M. Escalante, Joseph M. Christy, Rahul D. Pawar, Dwight H. Kono, Kenneth M. Pollard
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Immunology
Subjects:
silica
diversity outbred
autoimmunity
silicosis
autoantibody
inflammation
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00874/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00874/full

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