The pharmacology of TD-8954, a potent and selective 5-HT4 receptor agonist with gastrointestinal prokinetic properties

The pharmacology of TD-8954, a potent and selective 5-HT4 receptor agonist with gastrointestinal prokinetic properties

This study evaluated the in vitro and in vivo pharmacological properties of TD-8954, a potent and selective 5-HT4 receptor agonist. TD-8954 had high affinity (pKi = 9.4) for human recombinant 5-HT4(c) (h5-HT4(c)) receptors, and selectivity (> 2,000-fold) over all other 5-HT receptors and non...

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Bibliographic Details
Main Authors: David T Beattie, Scott R Armstrong, Ross G Vickery, Pam eTsuruda, Christina B Campbell, Carrie eRichardson, Julia eMcCullough, Oranee eDaniels, Kathryn eKersey, Yu-Ping eLi, Karl HS Kim
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-05-01
Series:Frontiers in Pharmacology
Subjects:
Constipation
Serotonin
5-HT4
prokinetic
TD-8954
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2011.00025/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2011.00025/full

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