A yeast model of FUS/TLS-dependent cytotoxicity.

A yeast model of FUS/TLS-dependent cytotoxicity.

FUS/TLS is a nucleic acid binding protein that, when mutated, can cause a subset of familial amyotrophic lateral sclerosis (fALS). Although FUS/TLS is normally located predominantly in the nucleus, the pathogenic mutant forms of FUS/TLS traffic to, and form inclusions in, the cytoplasm of affected s...

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Main Authors: Shulin Ju, Daniel F Tardiff, Haesun Han, Kanneganti Divya, Quan Zhong, Lynne E Maquat, Daryl A Bosco, Lawrence J Hayward, Robert H Brown, Susan Lindquist, Dagmar Ringe, Gregory A Petsko
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-04-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC3082520?pdf=render

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http://europepmc.org/articles/PMC3082520?pdf=render

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