Measurement of fasted state gastric antral motility before and after a standard bioavailability and bioequivalence 240 mL drink of water: Validation of MRI method against concomitant perfused manometry in healthy participants.

Measurement of fasted state gastric antral motility before and after a standard bioavailability and bioequivalence 240 mL drink of water: Validation of MRI method against concomitant perfused manometry in healthy participants.

<h4>Objective</h4>The gastrointestinal environment in which drug products need to disintegrate before the drug can dissolve and be absorbed has not been studied in detail due to limitations, especially invasiveness of existing techniques. Minimal in vivo data is available on undisturbed...

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Bibliographic Details
Main Authors: Khaled Heissam, Nichola Abrehart, Caroline L Hoad, Jeff Wright, Alex Menys, Kathryn Murray, Paul M Glover, Geoffrey Hebbard, Penny A Gowland, Jason Baker, William L Hasler, Robin C Spiller, Maura Corsetti, James G Brasseur, Bart Hens, Kerby Shedden, Joseph Dickens, Deanna M Mudie, Greg E Amidon, Gordon L Amidon, Luca Marciani
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0241441

Internet

https://doi.org/10.1371/journal.pone.0241441

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