L-3,4-Dihydroxyphenylalanine Recovers Circadian Rhythm Disturbances in the Rat Models of Parkinson's Disease by Regulating the D1R-ERK1/2-mTOR Pathway

L-3,4-Dihydroxyphenylalanine Recovers Circadian Rhythm Disturbances in the Rat Models of Parkinson's Disease by Regulating the D1R-ERK1/2-mTOR Pathway

Objective: Patients with Parkinson's disease (PD) frequently experience disruptions in the 24-h daily profile of both behavioral and biological markers. However, whether L-3,4-dihydroxyphenylalanine (L-dopa) influences these markers associated with circadian rhythm or not is still an open quest...

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Bibliographic Details
Main Authors: Shuyuan Yang, Ying Wan, Na Wu, Lu Song, Zhihua Liu, Jiahao Zhao, Ying Liu, Zhenguo Liu, Jing Gan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Aging Neuroscience
Subjects:
Parkinson's disease
Circadian rhythm
L-dopa
6-OHDA
BMAL1
mTOR
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2021.719885/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2021.719885/full

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