Isoform-Specific Roles of Mutant p63 in Human Diseases

The p63 gene encodes a master regulator of epidermal commitment, development, and differentiation. Heterozygous mutations in the DNA binding domain cause Ectrodactyly, Ectodermal Dysplasia, characterized by limb deformation, cleft lip/palate, and ectodermal dysplasia while mutations in in the C-term...

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Bibliographic Details
Main Authors: Christian Osterburg, Susanne Osterburg, Huiqing Zhou, Caterina Missero, Volker Dötsch
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cancers
Subjects:
p63
Online Access:https://www.mdpi.com/2072-6694/13/3/536