HSCs-derived COMP drives hepatocellular carcinoma progression by activating MEK/ERK and PI3K/AKT signaling pathways

HSCs-derived COMP drives hepatocellular carcinoma progression by activating MEK/ERK and PI3K/AKT signaling pathways

Abstract Background Cartilage oligomeric matrix protein (COMP) is known to promote fibrosis in skin, lung and liver. Emerging evidence shows that COMP plays critical roles in tumor development, including breast cancer, colon cancer and hepatocellular carcinoma (HCC). Nevertheless, the role of COMP i...

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Bibliographic Details
Main Authors: Qing Li, Cong Wang, Yufeng Wang, Liankang Sun, Zhikui Liu, Liang Wang, Tao Song, Yingmin Yao, Qingguang Liu, Kangsheng Tu
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Hepatocellular carcinoma
Microenvironment
Hepatic stellate cells
COMP
Tumor progression
Online Access:http://link.springer.com/article/10.1186/s13046-018-0908-y

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http://link.springer.com/article/10.1186/s13046-018-0908-y

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