GPR40 full agonism exerts feeding suppression and weight loss through afferent vagal nerve.

GPR40 full agonism exerts feeding suppression and weight loss through afferent vagal nerve.

GPR40/FFAR1 is a Gq protein-coupled receptor expressed in pancreatic β cells and enteroendocrine cells, and mediates insulin and incretin secretion to regulate feeding behavior. Several GPR40 full agonists have been reported to reduce food intake in rodents by regulating gut hormone secretion in add...

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Main Authors: Hikaru Ueno, Ryo Ito, Shin-Ichi Abe, Hitomi Ogino, Minoru Maruyama, Hirohisa Miyashita, Yasufumi Miyamoto, Yusuke Moritoh, Yoshiyuki Tsujihata, Koji Takeuchi, Nobuhiro Nishigaki
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0222653

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https://doi.org/10.1371/journal.pone.0222653

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