Calcitriol and Its Analogs Establish the Immunosuppressive Microenvironment That Drives Metastasis in 4T1 Mouse Mammary Gland Cancer

Calcitriol and Its Analogs Establish the Immunosuppressive Microenvironment That Drives Metastasis in 4T1 Mouse Mammary Gland Cancer

In our previous study, calcitriol and its analogs PRI-2191 and PRI-2205 stimulated 4T1 mouse mammary gland cancer metastasis. Therefore, we aimed to analyze the inflammatory response in 4T1-bearing mice treated with these compounds. Gene expression analysis of the splenocytes and regional lymph node...

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Bibliographic Details
Main Authors: Agata Pawlik, Artur Anisiewicz, Beata Filip-Psurska, Marcin Nowak, Eliza Turlej, Justyna Trynda, Joanna Banach, Paweł Gretkierewicz, Joanna Wietrzyk
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:International Journal of Molecular Sciences
Subjects:
calcitriol
vitamin D analogs
breast cancer
metastasis
immunosuppression
osteopontin
TGF-β
Online Access:http://www.mdpi.com/1422-0067/19/7/2116

Internet

http://www.mdpi.com/1422-0067/19/7/2116

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