Multivesicular body formation requires OSBP-related proteins and cholesterol.
In eukaryotes, different subcellular organelles have distinct cholesterol concentrations, which is thought to be critical for biological functions. Oxysterol-binding protein-related proteins (ORPs) have been assumed to mediate nonvesicular cholesterol trafficking in cells; however, their in vivo fun...
Main Authors: | , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2010-08-01
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Series: | PLoS Genetics |
Online Access: | http://europepmc.org/articles/PMC2916882?pdf=render |