Multivesicular body formation requires OSBP-related proteins and cholesterol.

Multivesicular body formation requires OSBP-related proteins and cholesterol.

In eukaryotes, different subcellular organelles have distinct cholesterol concentrations, which is thought to be critical for biological functions. Oxysterol-binding protein-related proteins (ORPs) have been assumed to mediate nonvesicular cholesterol trafficking in cells; however, their in vivo fun...

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Bibliographic Details
Main Authors: Hiroyuki Kobuna, Takao Inoue, Machiko Shibata, Keiko Gengyo-Ando, Akitsugu Yamamoto, Shohei Mitani, Hiroyuki Arai
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-08-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2916882?pdf=render

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