Distinct chromatin functional states correlate with HIV latency reactivation in infected primary CD4+ T cells

Distinct chromatin functional states correlate with HIV latency reactivation in infected primary CD4+ T cells

Human immunodeficiency virus (HIV) infection is currently incurable, due to the persistence of latently infected cells. The ‘shock and kill’ approach to a cure proposes to eliminate this reservoir via transcriptional activation of latent proviruses, enabling direct or indirect killing of infected ce...

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Bibliographic Details
Main Authors: Emilie Battivelli, Matthew S Dahabieh, Mohamed Abdel-Mohsen, J Peter Svensson, Israel Tojal Da Silva, Lillian B Cohn, Andrea Gramatica, Steven Deeks, Warner C Greene, Satish K Pillai, Eric Verdin
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-05-01
Series:eLife
Subjects:
HIV-1 latency
latency reversing agents
integration sites
latency reversal
reservoirs
Online Access:https://elifesciences.org/articles/34655

Internet

https://elifesciences.org/articles/34655

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