Deep sequencing of pre-translational mRNPs reveals hidden flux through evolutionarily conserved alternative splicing nonsense-mediated decay pathways

Deep sequencing of pre-translational mRNPs reveals hidden flux through evolutionarily conserved alternative splicing nonsense-mediated decay pathways

Abstract Background Alternative splicing, which generates multiple mRNA isoforms from single genes, is crucial for the regulation of eukaryotic gene expression. The flux through competing splicing pathways cannot be determined by traditional RNA-Seq, however, because different mRNA isoforms can have...

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Bibliographic Details
Main Authors: Carrie Kovalak, Scott Donovan, Alicia A. Bicknell, Mihir Metkar, Melissa J. Moore
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Genome Biology
Subjects:
Exon junctions
mRNA isoforms
AS-NMD
RIPiT-Seq
Pre-translational mRNPs
Splicing noise
Online Access:https://doi.org/10.1186/s13059-021-02309-y

Internet

https://doi.org/10.1186/s13059-021-02309-y

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