A TrkB agonist and ampakine rescue synaptic plasticity and multiple forms of memory in a mouse model of intellectual disability

A TrkB agonist and ampakine rescue synaptic plasticity and multiple forms of memory in a mouse model of intellectual disability

Fragile X syndrome (FXS) is associated with deficits in various types of learning, including those that require the hippocampus. Relatedly, hippocampal long-term potentiation (LTP) is impaired in the Fmr1 knockout (KO) mouse model of FXS. Prior research found that infusion of brain-derived neurotrop...

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Bibliographic Details
Main Authors: Ronald R. Seese, Aliza A. Le, Kathleen Wang, Conor D. Cox, Gary Lynch, Christine M. Gall
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:Neurobiology of Disease
Subjects:
Fragile X syndrome
TrkB
Ampakine
Object location memory
7,8-dihydroxyflavone
Social approach
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996119302797

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http://www.sciencedirect.com/science/article/pii/S0969996119302797

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