Tetranucleotide and Low Microsatellite Instability Are Inversely Associated with the CpG Island Methylator Phenotype in Colorectal Cancer

Tetranucleotide and Low Microsatellite Instability Are Inversely Associated with the CpG Island Methylator Phenotype in Colorectal Cancer

<i>MSH3</i> gene or protein deficiency or loss-of-function in colorectal cancer can cause a DNA mismatch repair defect known as “elevated microsatellite alterations at selected tetranucleotide repeats” (EMAST). A high percentage of MSI-H tumors exhibit EMAST, while MSI-L is also linked w...

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Bibliographic Details
Main Authors: Sabine Meessen, Nicola Currey, Zeenat Jahan, Hannah W. Parker, Mark A. Jenkins, Daniel D. Buchanan, John L. Hopper, Eva Segelov, Jane E. Dahlstrom, Maija R. J. Kohonen-Corish
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cancers
Subjects:
EMAST
MSI-H
MSI-L
CIMP
colorectal cancer
<i>CDKN2A</i>
Online Access:https://www.mdpi.com/2072-6694/13/14/3529

Internet

https://www.mdpi.com/2072-6694/13/14/3529

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