Targeting Amino Acid Metabolic Reprogramming via L-Type Amino Acid Transporter 1 (LAT1) for Endocrine-Resistant Breast Cancer

Targeting Amino Acid Metabolic Reprogramming via L-Type Amino Acid Transporter 1 (LAT1) for Endocrine-Resistant Breast Cancer

The PI3K/Akt/mTOR pathway has been well known to interact with the estrogen receptor (ER)-pathway and to be also frequently upregulated in aromatase inhibitor (AI)-resistant breast cancer patients. Intracellular levels of free amino acids, especially leucine, regulate the mammalian target of rapamyc...

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Bibliographic Details
Main Authors: Haruhiko Shindo, Narumi Harada-Shoji, Akiko Ebata, Miku Sato, Tomoyoshi Soga, Minoru Miyashita, Hiroshi Tada, Masaaki Kawai, Shinkichi Kosaka, Koji Onuki, Shin Usami, Shozo Furumoto, Shinichi Hayashi, Takaaki Abe, Takashi Suzuki, Takanori Ishida, Hironobu Sasano
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cancers
Subjects:
SLC7A5 (LAT1)
SLC43A1 (LAT3)
breast cancer
hormone therapy
amino acid metabolism
JPH203
Online Access:https://www.mdpi.com/2072-6694/13/17/4375

Internet

https://www.mdpi.com/2072-6694/13/17/4375

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