Treatment Efficiency of Free and Nanoparticle-Loaded Mitoxantrone for Magnetic Drug Targeting in Multicellular Tumor Spheroids

Treatment Efficiency of Free and Nanoparticle-Loaded Mitoxantrone for Magnetic Drug Targeting in Multicellular Tumor Spheroids

Major problems of cancer treatment using systemic chemotherapy are severe side effects. Magnetic drug targeting (MDT) employing superparamagnetic iron oxide nanoparticles (SPION) loaded with chemotherapeutic agents may overcome this dilemma by increasing drug accumulation in the tumor and reducing t...

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Bibliographic Details
Main Authors: Annkathrin Hornung, Marina Poettler, Ralf P. Friedrich, Jan Zaloga, Harald Unterweger, Stefan Lyer, Johannes Nowak, Stefan Odenbach, Christoph Alexiou, Christina Janko
Format: Article
Language:English
Published: MDPI AG 2015-09-01
Series:Molecules
Subjects:
nanomedicine
magnetic drug targeting
superparamagnetic iron oxide nanoparticles
multicellular tumor spheroids
chemotherapy
Online Access:http://www.mdpi.com/1420-3049/20/10/18016

Internet

http://www.mdpi.com/1420-3049/20/10/18016

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