Amylin receptor insensitivity impairs hypothalamic POMC neuron differentiation in the male offspring of maternal high-fat diet-fed mice

Objective: Amylin was found to regulate glucose and lipid metabolism by acting on the arcuate nucleus of the hypothalamus (ARC). Maternal high-fat diet (HFD) induces sex-specific metabolic diseases mediated by the ARC in offspring. This study was performed to explore 1) the effect of maternal HFD-in...

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Bibliographic Details
Main Authors: Cheng Li, Jing-Jing Xu, Hong-Tao Hu, Chao-Yi Shi, Chuan-Jin Yu, Jian-Zhong Sheng, Yan-Ting Wu, He-Feng Huang
Format: Article
Language:English
Published: Elsevier 2021-02-01
Series:Molecular Metabolism
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S221287782030209X