Tenfibgen ligand nanoencapsulation delivers bi-functional anti-CK2 RNAi oligomer to key sites for prostate cancer targeting using human xenograft tumors in mice.

Tenfibgen ligand nanoencapsulation delivers bi-functional anti-CK2 RNAi oligomer to key sites for prostate cancer targeting using human xenograft tumors in mice.

Protected and specific delivery of nucleic acids to malignant cells remains a highly desirable approach for cancer therapy. Here we present data on the physical and chemical characteristics, mechanism of action, and pilot therapeutic efficacy of a tenfibgen (TBG)-shell nanocapsule technology for tum...

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Bibliographic Details
Main Authors: Janeen H Trembley, Gretchen M Unger, Vicci L Korman, Md Joynal Abedin, Lucas P Nacusi, Rachel I Vogel, Joel W Slaton, Betsy T Kren, Khalil Ahmed
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4198192?pdf=render

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http://europepmc.org/articles/PMC4198192?pdf=render

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