ACPA-negative RA consists of two genetically distinct subsets based on RF positivity in Japanese.

ACPA-negative RA consists of two genetically distinct subsets based on RF positivity in Japanese.

HLA-DRB1, especially the shared epitope (SE), is strongly associated with rheumatoid arthritis (RA). However, recent studies have shown that SE is at most weakly associated with RA without anti-citrullinated peptide/protein antibody (ACPA). We have recently reported that ACPA-negative RA is associat...

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Bibliographic Details
Main Authors: Chikashi Terao, Koichiro Ohmura, Katsunori Ikari, Yuta Kochi, Etsuko Maruya, Masaki Katayama, Kimiko Yurugi, Kota Shimada, Akira Murasawa, Shigeru Honjo, Kiyoshi Takasugi, Keitaro Matsuo, Kazuo Tajima, Akari Suzuki, Kazuhiko Yamamoto, Shigeki Momohara, Hisashi Yamanaka, Ryo Yamada, Hiroo Saji, Fumihiko Matsuda, Tsuneyo Mimori
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3391228?pdf=render

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http://europepmc.org/articles/PMC3391228?pdf=render

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