Human Properdin Opsonizes Nanoparticles and Triggers a Potent Pro-inflammatory Response by Macrophages without Involving Complement Activation

Human Properdin Opsonizes Nanoparticles and Triggers a Potent Pro-inflammatory Response by Macrophages without Involving Complement Activation

Development of nanoparticles as tissue-specific drug delivery platforms can be considerably influenced by the complement system because of their inherent pro-inflammatory and tumorigenic consequences. The complement activation pathways, and its recognition subcomponents, can modulate clearance of th...

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Bibliographic Details
Main Authors: Lubna Kouser, Basudev Paudyal, Anuvinder Kaur, Gudrun Stenbeck, Lucy A. Jones, Suhair M. Abozaid, Cordula M. Stover, Emmanuel Flahaut, Robert B. Sim, Uday Kishore
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Immunology
Subjects:
carbon nanotubes
complement
properdin
thrombospondin repeats
phagocytosis
inflammation
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00131/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00131/full

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