Fetal hematopoietic stem cell homing is controlled by VEGF regulating the integrity and oxidative status of the stromal-vascular bone marrow niches

Fetal hematopoietic stem cell homing is controlled by VEGF regulating the integrity and oxidative status of the stromal-vascular bone marrow niches

Summary: Hematopoietic stem and progenitor cell (HSPC) engraftment after transplantation during anticancer treatment depends on support from the recipient bone marrow (BM) microenvironment. Here, by studying physiological homing of fetal HSPCs, we show the critical requirement of balanced local cros...

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Bibliographic Details
Main Authors: Marion Mesnieres, Anna-Marei Böhm, Nicolas Peredo, Dana Trompet, Roger Valle-Tenney, Manmohan Bajaj, Nikky Corthout, Elena Nefyodova, Ruben Cardoen, Pieter Baatsen, Sebastian Munck, Andras Nagy, Jody J. Haigh, Satish Khurana, Catherine M. Verfaillie, Christa Maes
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Cell Reports
Subjects:
hematopoietic stem cell
niche
bone marrow
angiogenesis
stromal cell
hematopoiesis
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721010561

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http://www.sciencedirect.com/science/article/pii/S2211124721010561

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