Comparison of Mesenchymal Stromal Cells From Different Origins for the Treatment of Graft-vs.-Host-Disease in a Humanized Mouse Model

Comparison of Mesenchymal Stromal Cells From Different Origins for the Treatment of Graft-vs.-Host-Disease in a Humanized Mouse Model

Mesenchymal stromal cells (MSCs) have potent immunomodulatory properties that make them an attractive tool against graft- vs.-host disease (GVHD). However, despite promising results in phase I/II studies, bone marrow (BM-) derived MSCs failed to demonstrate their superiority over placebo in the sole...

Full description

Bibliographic Details
Main Authors: Céline Grégoire, Caroline Ritacco, Muriel Hannon, Laurence Seidel, Loïc Delens, Ludovic Belle, Sophie Dubois, Sophie Vériter, Chantal Lechanteur, Alexandra Briquet, Sophie Servais, Gregory Ehx, Yves Beguin, Frédéric Baron
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Immunology
Subjects:
mesenchymal stromal cells
graft-vs.-host-disease
hematopoietic stem cell transplantation
xenogeneic
NSG
bone marrow
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00619/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00619/full

Similar Items