A Series of Isatin-Hydrazones with Cytotoxic Activity and CDK2 Kinase Inhibitory Activity: A Potential Type II ATP Competitive Inhibitor

A Series of Isatin-Hydrazones with Cytotoxic Activity and CDK2 Kinase Inhibitory Activity: A Potential Type II ATP Competitive Inhibitor

Isatin derivatives potentially act on various biological targets. In this article, a series of novel isatin-hydrazones were synthesized in excellent yields. Their cytotoxicity was tested against human breast adenocarcinoma (MCF7) and human ovary adenocarcinoma (A2780) cell lines using MTT assay. Com...

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Bibliographic Details
Main Authors: Huda S. Al-Salem, Md Arifuzzaman, Hamad M. Alkahtani, Ashraf N. Abdalla, Iman S. Issa, Aljawharah Alqathama, Fatemah S. Albalawi, A. F. M. Motiur Rahman
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Molecules
Subjects:
isatin-hydrazones
cytotoxicity
CDK2 inhibitor
ATP competitive inhibitor
ADME analysis
Online Access:https://www.mdpi.com/1420-3049/25/19/4400

Internet

https://www.mdpi.com/1420-3049/25/19/4400

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