In vivo 2H2O administration reveals impaired triglyceride storage in adipose tissue of insulin-resistant humans1

In vivo 2H2O administration reveals impaired triglyceride storage in adipose tissue of insulin-resistant humans1

Indirect evidence suggests that impaired triglyceride storage in the subcutaneous fat depot contributes to the development of insulin resistance via lipotoxicity. We directly tested this hypothesis by measuring, in vivo, TG synthesis, de novo lipogenesis (DNL), adipocyte proliferation, and insulin s...

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Bibliographic Details
Main Authors: Candice A. Allister, Li-fen Liu, Cindy A. Lamendola, Colleen M. Craig, Samuel W. Cushman, Marc K. Hellerstein, Tracey L. McLaughlin
Format: Article
Language:English
Published: Elsevier 2015-02-01
Series:Journal of Lipid Research
Subjects:
obesity
insulin resistance
subcutaneous adipose
triglycerides
de novo
lipogenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520356273

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http://www.sciencedirect.com/science/article/pii/S0022227520356273

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