TMEM120A is a coenzyme A-binding membrane protein with structural similarities to ELOVL fatty acid elongase

TMEM120A, also named as TACAN, is a novel membrane protein highly conserved in vertebrates and was recently proposed to be a mechanosensitive channel involved in sensing mechanical pain. Here we present the single-particle cryogenic electron microscopy (cryo-EM) structure of human TMEM120A, which fo...

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Bibliographic Details
Main Authors: Jing Xue, Yan Han, Hamid Baniasadi, Weizhong Zeng, Jimin Pei, Nick V Grishin, Junmei Wang, Benjamin P Tu, Youxing Jiang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-08-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/71220