Enhancement of solubility and therapeutic potential of poorly soluble lovastatin by SMEDDS formulation adsorbed on directly compressed spray dried magnesium aluminometasilicate liquid loadable tablets: A study in diet induced hyperlipidemic rabbits

Enhancement of solubility and therapeutic potential of poorly soluble lovastatin by SMEDDS formulation adsorbed on directly compressed spray dried magnesium aluminometasilicate liquid loadable tablets: A study in diet induced hyperlipidemic rabbits

The aim of present study was to formulate and evaluate a self-microemulsifying drug delivery systems (SMEDDS) containing lovastatin and to further explore the ability of porous Neusilin® US2 tablet as a solid carrier for SMEDDS. SMEDDS formulations of varying proportions of peceol, cremophor RH 40 a...

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Bibliographic Details
Main Authors: Mohd Javed Qureshi, Chitneni Mallikarjun, Wong Gan Kian
Format: Article
Language:English
Published: Elsevier 2015-02-01
Series:Asian Journal of Pharmaceutical Sciences
Subjects:
Lovastatin
Self-microemulsifying drug delivery system (SMEDDS)
Neusilin® US2
Liquid loadable tablet
Solid carrier system
Pharmacodynamics studies
Online Access:http://www.sciencedirect.com/science/article/pii/S181808761400052X

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http://www.sciencedirect.com/science/article/pii/S181808761400052X

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